Miniaturized bone marrow-on-a-chip tracks human immune cells as they build lasting antibody defenses

A scientific team has developed a laboratory model that reveals how antibody-producing plasma cells migrate, mature and survive within human bone marrow, a main location of long-lived antibody-producing plasma cells. The platform combines a lymph node-mimicking organoid with a tissue chip that mimics bone marrow, allowing scientists to observe key stages of plasma cell development that have been difficult to study in humans.

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