Protein shape shift reveals how the mpox virus begins replicating

The way two mpox virus proteins change shape as they bind together acts like a switch that starts the process of viral replication, a study led by researchers at the Blavatnik Institute at Harvard Medical School reveals. This kind of detailed structural information promises to help scientists, armed with a new generation of AI-powered virtual screening tools, target their search for ways to inhibit viral replication, treat mpox and related diseases, and prepare for emerging pathogens.

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