Nasal spray vaccine protects against bird flu in mice

WashU Medicine researchers led by Jacco Boon, a professor in the John T. Milliken Department of Medicine, report that an experimental bird flu vaccine provides strong immune protection in mice, including in animals previously vaccinated against seasonal flu. Because pre-existing immunity from prior seasonal influenza infection or vaccination could diminish the efficacy of H5N1 vaccines, showing that the new vaccine succeeds alongside existing immunity is a crucial milestone.

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