Spatial atlas reveals how ovarian clear cell tumors vary from core to edge

Ovarian clear cell carcinoma (OCCC) has a higher prevalence among East Asian women and is characterized by poor clinical outcomes. An interdisciplinary team led by Professor Ruby Yun-Ju Huang at National Taiwan University College of Medicine has established a comprehensive spatial atlas of OCCC, revealing how distinct tumor cell populations are organized within the same tumor and identifying a key molecular regulator of tumor plasticity.