Stress proteins actively sustain joint inflammation in osteoarthritis, study finds

Why do some joints remain chronically inflamed in osteoarthritis and other rheumatic diseases? Researchers have taken an important step toward answering this question. Their findings, published in the journal Cell Death & Differentiation, highlight the key role of proteins associated with endoplasmic reticulum (ER) stress, a cellular mechanism that has so far been only sparsely investigated in human joint tissues.

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