Remote-control in the cortex—how distant synapses are equipped for change

The outermost layer of the brain's cerebral cortex is a major meeting point for information coming from across the brain. Researchers at the Max Planck Institute for Brain Research have now discovered that synapses in this thin layer can produce proteins locally. Published in Cell Reports, the study provides the first comprehensive molecular map of cortical layer 1 and its synapses, revealing a specialized signature and unexpected similarities with the hippocampus.

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