How the APOE4 gene damages brain blood vessels in Alzheimer's disease

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease. Published in Cell and Cell Stem Cell, the studies identify potentially reversible disease mechanisms and demonstrate how a new stem cell-derived human brain tissue platform can accelerate mechanistic discovery and therapeutic development.

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